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Article

Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington's disease.

Experimental neurology - 1 Sept 2008

Wolf Robert Christian, Sambataro Fabio, Vasic Nenad, Schönfeldt-Lecuona Carlos, Ecker Daniel, Landwehrmeyer Bernhard

Abstract excerpt

In clinically presymptomatic individuals with the Huntington's disease (HD) gene mutation, functional neuroimaging data have suggested a dysfunction of multiple cortical and subcortical regions including the prefrontal and parietal cortex, as well as the striatum. Although it has been hypothesized that these activation differences most likely reflect aberrant corticostriatal circuits, the functional coupling of...

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Identifiers

PMID: 18588876
DOI: 10.1016/j.expneurol.2008.05.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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