Article
Functional compensation or pathology in cortico-subcortical interactions in preclinical Huntington's disease?
Neuropsychologia - 1 Oct 2007
Beste Christian, Saft Carsten, Yordanova Juliana, Andrich Jürgen, Gold Ralf, Falkenstein Michael, Kolev Vasil
Abstract excerpt
Huntington's disease (HD) is an autosomal dominant neurological disorder, with degeneration amongst others affecting the basal ganglia dopaminergic system. Recent findings suggest compensatory as well as pathogenetic mechanisms mediated via the adenosine receptor system in the presymptomatic stage (pHD) of HD. The adenosine receptor system is functionally related to the dopaminergic system. In this study, we...
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