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Article

Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling.

Neuron - 8 May 2013

Földy Csaba, Malenka Robert C, Südhof Thomas C

Abstract excerpt

Neuroligins are postsynaptic cell-adhesion molecules that interact with presynaptic neurexins. Rare mutations in neuroligins and neurexins predispose to autism, including a neuroligin-3 amino acid substitution (R451C) and a neuroligin-3 deletion. Previous analyses showed that neuroligin-3 R451C-knockin mice exhibit robust synaptic phenotypes but failed to uncover major changes in neuroligin-3 knockout mice,...

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Identifiers

PMID: 23583622
DOI: 10.1016/j.neuron.2013.02.036
PMCID: PMC3663050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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