Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A robust in vivo model for B cell precursor acute lymphoblastic leukemia.

The Journal of clinical investigation - 1 Sept 2015

Fry Terry J, Aplan Peter D

Abstract excerpt

B cell precursor acute lymphoblastic leukemia (BCP ALL) is the most common malignancy in children. While treatments have improved remarkably over the past four decades, resistant disease and late effects that result from cytotoxic chemotherapy remain serious problems for individuals with BCP ALL. Improved genetic tools have led to the discovery of numerous somatic mutations associated with BCP ALL, leading to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Janus Kinases
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Proteins

Share to PAX5 Transcription Factor

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Signal Transduction

Share to STAT Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26301807
DOI: 10.1172/JCI83799
PMCID: PMC4588242

Genes

PAX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A robust in vivo model for B cell precursor acute lymphoblastic leukemia.PMID 26301807Read ↗

GEMMs addressing Pax5 loss-of-function in childhood pB-ALL.Semantic proximity Read ↗

PAX5 alterations in B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemiaSemantic proximity Read ↗

Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.Semantic proximity Read ↗

Modeling the PAX5P80R Mutation Reveals HIF2α Activation as a Common Feature and Therapeutic Target in B-cell Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

A platform of robust patient-derived leukemia models covering subgroups for which no cell lines existSemantic proximity Read ↗

Utility of a Large Series of B‐Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model SystemSemantic proximity Read ↗

PAX5 as a diagnostic tool in unconventional acute leukemia: Establishing immunohistochemical evidence of B-cell lineageSemantic proximity Read ↗

NOTCH1-Induced T-Cell Acute Lymphoblastic Leukemia In Vivo Models.Semantic proximity Read ↗

Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesisSemantic proximity Read ↗

Murine Models of Acute Leukemia: Important Tools in Current Pediatric Leukemia ResearchSemantic proximity Read ↗

Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.