Article
Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer.
Oncotarget - 4 Apr 2017
Pécuchet Nicolas, Laurent-Puig Pierre, Mansuet-Lupo Audrey, Legras Antoine, Alifano Marco, Pallier Karine, Didelot Audrey, Gibault Laure, Danel Claire, Just Pierre-Alexandre, Riquet Marc, Le Pimpec-Barthes Françoise, Damotte Diane, Fabre Elisabeth, Blons Hélène
Abstract excerpt
STK11 is commonly mutated in lung cancer. In light of recent experimental data showing that specific STK11 mutants could acquire oncogenic activities due to the synthesis of a short STK11 isoform, we investigated whether this new classification of STK11 mutants could help refine its role as a prognostic marker. We conducted a retrospective high-throughput genotyping study in 567 resected non-squamous...
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