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Article

Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers.

Carcinogenesis - 31 Dec 2021

Donnelly Liam L, Hogan Tyler C, Lenahan Sean M, Nandagopal Gopika, Eaton Jenna G, Lebeau Meagan A, McCann Cai L, Sarausky Hailey M, Hampel Kenneth J, Armstrong Jordan D, Cameron Margaret P, Sidiropoulos Nikoletta, Deming Paula, Seward David J

Abstract excerpt

Serine/Threonine Kinase 11 (STK11) encodes an important tumor suppressor that is frequently mutated in lung adenocarcinoma. Clinical studies have shown that mutations in STK11 resulting in loss of function correlate with resistance to anti-PD-1 monoclonal antibody therapy in KRAS-driven non-small cell lung cancer (NSCLC), but the molecular mechanisms responsible remain unclear. Despite this uncertainty, STK11...

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Identifiers

PMID: 34849607
DOI: 10.1093/carcin/bgab104
PMCID: PMC8727739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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