Article
The potential clinical benefit of routine comprehensive genomic profiling in non-small cell lung cancer for the detection of prognostic co-mutations - A multicenter next generation sequencing study.
Cancer treatment and research communications - 1 Jan 2026
Soekhoe Shaylin A, Dingemans Anne-Marie C, van Kemenade Folkert J, Rouse Remigio W, Yick David C Y, van der Leest Cor H, Dubbink Hendrikus Jan, von der Thüsen Jan H
Abstract excerpt
INTRODUCTION: Non-driver mutations such as TP53, STK11 and KEAP1 are clinically relevant in determining immunotherapy efficacy in patients with non-small cell lung cancer (NSCLC). The aim of this study is to determine the prevalence and clinical relevance of variations in TP53, STK11 and KEAP1 in patients in the analysis of NSCLC, using targeted next-generation sequencing. METHODS: This real-life prospective...
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