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Article

LKB1/STK11 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2017

Facchinetti Francesco, Bluthgen Maria Virginia, Tergemina-Clain Gabrielle, Faivre Laura, Pignon Jean-Pierre, Planchard David, Remon Jordi, Soria Jean-Charles, Lacroix Ludovic, Besse Benjamin

Abstract excerpt

BACKGROUND: LKB1/STK11 (STK11) is among the most inactivated tumor-suppressor genes in non-small cell lung cancer (NSCLC). While evidence concerning the biologic role of STK11 is accumulating, its prognostic significance in advanced NSCLC has not been envisaged yet. MATERIALS AND METHODS: This retrospective analysis included consecutive NSCLC patients with available STK11 information who underwent a...

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Identifiers

PMID: 29191602
DOI: 10.1016/j.lungcan.2017.08.002

Genes

STK11
KRAS

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