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Article

Clinical impact of STK11 mutation in advanced-stage non-small cell lung cancer.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2022

Rosellini Pietro, Amintas Samuel, Caumont Charline, Veillon Rémi, Galland-Girodet Sigolène, Cuguillière Alain, Nguyen Laurent, Domblides Charlotte, Gouverneur Amandine, Merlio Jean-Philippe, Bezin Julien, Girodet Pierre-Olivier

Abstract excerpt

BACKGROUND: Mutations in STK11/LKB1 gene present a negative impact on tumour immune microenvironment, especially with concomitant activating KRAS mutation. These recent data may explain a decreased response to immunotherapy treatment in STK11 mutant non-small cell lung cancer (NSCLC). OBJECTIVE: The primary objective is to evaluate, in a real-life setting, overall survival (OS) in patients with NSCLC according to...

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Identifiers

PMID: 35759814
DOI: 10.1016/j.ejca.2022.05.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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