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STK11/LKB1 alterations worsen the poor prognosis of KRAS mutated early-stage non-squamous non-small cell lung carcinoma, results based on the phase 2 IFCT TASTE trial.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2024

Oudart Jean Baptiste, Garinet Simon, Leger Caroline, Barlesi Fabrice, Mazières Julien, Jeannin Gaelle, Audigier-Valette Clarisse, Morot-Sibilot Denis, Langlais Alexandra, Amour Elodie, Mathiot Nathalie, Birsen Gary, Blons Hélène, Wislez Marie

Abstract excerpt

BACKGROUND: STK11/LKB1 mutations have been associated with primary resistance to PD-1 axis inhibitors and poor prognosis in advanced KRAS-mutant lung adenocarcinoma. This study aimed to assess the prognostic significance of STK11/LKB1 alterations in localized non-squamous non-small cell lung carcinoma (non-sq NSCLC). PATIENTS AND METHODS: Surgical samples from patients undergoing complete resection for stage IIa,...

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Adenocarcinoma of Lung
AMP-Activated Protein Kinase Kinases
B7-H1 Antigen
Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Recurrence, Local

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 38428265
DOI: 10.1016/j.lungcan.2024.107508

Genes

KRAS
STK11
EGFR
ERCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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STK11/LKB1 alterations worsen the poor prognosis of KRAS mutated early-stage non-squamous non-small cell lung carcinoma, results based on the phase 2 IFCT TASTE trial.PMID 38428265Read ↗

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