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Article

Impact of TP53, KEAP1 and STK11 mutations in localized-stage NSCLC: A European thoracic oncology platform lungscape project.

European journal of cancer (Oxford, England : 1990) - 9 Sept 2026

Molina-Vila Miguel A, Tsourti Zoi, Vervita Katerina, Bertran-Alamillo Jordi, García-Peláez Beatriz, Kerr Keith M, Bubendorf Lukas, Madsen Line Bille, Biernat Wojciech, Stenzinger Albrecht, Haberecker Martina, Blackhall Fiona, Pokharel Saraswati, Jordana-Ariza Núria, Vives-Usano Marta, Vagenknecht Patrick, Dafni Urania, Kammler Roswitha, Finn Stephen P, Peters Solange, Stahel Rolf A, Rosell Rafael

Abstract excerpt

BACKGROUND: TP53, STK11 and KEAP1 mutations are frequent in localized-stage non-small cell lung cancer (NSCLC). However, their prognostic and predictive role has not been fully investigated, particularly in relation to adjuvant treatment. METHODS: Tumor samples from a training cohort of 350 surgically resected ETOP Lungscape NSCLC patients and a validation cohort of 161 additional patients were genotyped using...

Topics

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AMP-Activated Protein Kinase Kinases
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kelch-Like ECH-Associated Protein 1

Neoplasm Staging

Protein Serine-Threonine Kinases

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 41723072
DOI: 10.1016/j.ejca.2026.116583

Genes

TP53
KEAP1
STK11
TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Impact of TP53, KEAP1 and STK11 mutations in localized-stage NSCLC: A European thoracic oncology platform lungscape project.PMID 41723072Read ↗

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