Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformation

1 Mar 2012

Abstract excerpt

Active avoidance by tumor cells from attack and elimination by immune cells is an emerging cancer hallmark that is achieved primarily through decreasing the levels of major histocompatibility complex class I (MHC-I) at the cancer cells' surface. Deficiencies in MHC-I antigen-restricted immunosurveillance may be intertwined with an altered, Warburg-like cancer cell-intrinsic metabolism, another emerging hallmark...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immune Cell Function and Interaction
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22333588
DOI: 10.4161/cc.11.5.19252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformationPMID 22333588Read ↗

Warburg Effect Reshapes Tumor Immunogenicity.Semantic proximity Read ↗

Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma.Semantic proximity Read ↗

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockadeSemantic proximity Read ↗

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defencesSemantic proximity Read ↗

Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells.Semantic proximity Read ↗

Metabolically inducing defects in DNA repair sensitizes BRCA –wild-type cancer cells to replication stressSemantic proximity Read ↗

Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitors.Semantic proximity Read ↗

Immune evasion through mitochondrial transfer in the tumour microenvironment.Semantic proximity Read ↗

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistanceSemantic proximity Read ↗

Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolismSemantic proximity Read ↗

T cell metabolic insufficiency explains the dysfunctional immune response in advanced renal cell carcinoma.Semantic proximity Read ↗

Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.