Article
Natural course of preclinical type 1 diabetes.
Hormone research - 1 Jan 2002
Knip Mikael
Abstract excerpt
The clinical presentation of type 1 diabetes is preceded by an asymptomatic latent period characterized by the presence of diabetes-associated autoantibodies in the peripheral circulation, reflecting beta-cell damage. This prediabetic period may last for months and years. Several studies observing genetically susceptible subjects from birth have shown that insulin autoantibodies (IAA) are the first or among the...
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