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Increasing plasma glucose before the development of type 1 diabetes-the TRIGR study.

Pediatric diabetes - 1 Nov 2021

Ludvigsson Johnny, Cuthbertson David, Becker Dorothy J, Kordonouri Olga, Aschemeier Bärbel, Pacaud Daniele, Clarson Cheril, Krischer Jeffrey P, Knip Mikael

Abstract excerpt

OBJECTIVE: The β-cell stress hypothesis suggests that increased insulin demand contributes to the development of type 1 diabetes. In the TRIGR trial we set out to assess the profile of plasma glucose and HbA1c before the diagnosis of clinical diabetes compared to nondiabetic children. RESEARCH DESIGN AND METHODS: A cohort of children (N = 2159) with an affected first-degree relative and increased HLA risk were...

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Source

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Identifiers

PMID: 34369627
DOI: 10.1111/pedi.13251
PMCID: PMC8530903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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