Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

(1)H NMR metabolomics analysis of renal cell carcinoma cells: Effect of VHL inactivation on metabolism.

International journal of cancer - 15 May 2016

Cuperlovic-Culf Miroslava, Cormier Kevin, Touaibia Mohamed, Reyjal Julie, Robichaud Sarah, Belbraouet Mehdi, Turcotte Sandra

Abstract excerpt

Von Hippel-Lindau (VHL) is an onco-suppressor involved in oxygen and energy-dependent promotion of protein ubiquitination and proteosomal degradation. Loss of function mutations of VHL (VHL-cells) result in organ specific cancers with the best studied example in renal cell carcinomas. VHL has a well-established role in deactivation of hypoxia-inducible factor (HIF-1) and in regulation of PI3K/AKT/mTOR activity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Kidney Neoplasms

Share to Metabolome

Share to Metabolomics

Share to Proton Magnetic Resonance Spectroscopy

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 26620126
DOI: 10.1002/ijc.29947

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

(1)H NMR metabolomics analysis of renal cell carcinoma cells: Effect of VHL inactivation on metabolism.PMID 26620126Read ↗

Metabolic landscape of clear cell renal cell carcinoma and search for metabolites predictive of drug responseSemantic proximity Read ↗

Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression.Semantic proximity Read ↗

New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease.Semantic proximity Read ↗

Unraveling the Rewired Metabolism in Lung Cancer Using Quantitative NMR Metabolomics.Semantic proximity Read ↗

The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell CarcinomaSemantic proximity Read ↗

An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancerSemantic proximity Read ↗

Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinomaSemantic proximity Read ↗

The genetic basis of kidney cancer: a metabolic disease.Semantic proximity Read ↗

The Heterogeneity Metabolism of Renal Cell Carcinomas.Semantic proximity Read ↗

Formation of Renal Cysts and Tumors in <i>Vhl/Trp53</i> -Deficient Mice Requires HIF1α and HIF2αSemantic proximity Read ↗

Opportunities for studying cancer by metabolomics: preliminary observations on tumors deficient in hypoxia-inducible factor 1.Semantic proximity Read ↗

Hypoxia-inducible factors drive miRNA-mediated downregulation of <i>L2HGDH</i> and <i>HIF1A</i> in clear cell renal cancer independent of 14q deletionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.