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Article

The genetic basis of kidney cancer: a metabolic disease.

Nature reviews. Urology - 1 May 2010

Linehan W Marston, Srinivasan Ramaprasad, Schmidt Laura S

Abstract excerpt

Kidney cancer is not a single disease but comprises a number of different types of cancer that occur in the kidney, each caused by a different gene with a different histology and clinical course that responds differently to therapy. Each of the seven known kidney cancer genes, VHL, MET, FLCN, TSC1, TSC2, FH and SDH, is involved in pathways that respond to metabolic stress or nutrient stimulation. The VHL protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20448661
DOI: 10.1038/nrurol.2010.47
PMCID: PMC2929006

Genes

TSC1
FLCN
MET
TSC2
VHL
FNIP1
FNIP2
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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