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Article

An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancer

2020-12-10

Abstract excerpt

Hypermethylation of tumor suppressors and other aberrations of DNA methylation in tumors play a significant role in cancer progression. DNA methylation can be affected by various environmental conditions including hypoxia. The response to hypoxia is mainly achieved through activation of the transcription program associated with HIF1a transcription factor. VHL inactivation by genetic or epigenetic events, which als...

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Literature Corpus work
c21a2a2a-096c-5a6b-bed7-37d15b5d995f
DOI
10.1101/2020.12.09.418616
Open publication

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An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancerDOI 10.1101/2020.12.09.418616
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