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Article

Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Feb 2009

Ortiz Jorge G Muñiz, Opoka Robert, Kane Daniel, Cartwright Iain L

Abstract excerpt

Chronic exposure to arsenic-contaminated drinking water can lead to a variety of serious pathological outcomes. However, differential responsiveness within human populations suggests that interindividual genetic variation plays an important role. We are using Drosophila to study toxic metal response pathways because of unrivalled access to varied genetic approaches and significant demonstrable overlap with many...

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Identifiers

PMID: 18779381
DOI: 10.1093/toxsci/kfn192
PMCID: PMC2639754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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