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Article

Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing.

Genetics - 3 Mar 2022

Macdonald Stuart J, Cloud-Richardson Kristen M, Sims-West Dylan J, Long Anthony D

Abstract excerpt

Despite the value of recombinant inbred lines for the dissection of complex traits, large panels can be difficult to maintain, distribute, and phenotype. An attractive alternative to recombinant inbred lines for many traits leverages selecting phenotypically extreme individuals from a segregating population, and subjecting pools of selected and control individuals to sequencing. Under a bulked or extreme...

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PMID: 35100395
DOI: 10.1093/genetics/iyab238
PMCID: PMC8893256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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