Article
Rapid detection of rifampicin resistance in Mycobacterium tuberculosis by high-resolution melting curve analysis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Dec 2015
Malhotra B, Goyal S, Bhargava S, Reddy P V J, Chauhan A, Tiwari J
Abstract excerpt
SETTING: High-resolution melting curve analysis (HRMA) can be used to screen for mutations in genes without the need for specific probes, with low turnaround time and high cost-effectiveness. OBJECTIVE: To detect the sensitivity and specificity of a line-probe assay (LPA) and HRMA in comparison with BACTEC™ MGIT™ 960 for the detection of rifampicin (RMP) resistance. DESIGN: A total of 219 Mycobacterium...
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