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Article

High resolution melting curve assay for rapid detection of drug-resistant Mycobacterium tuberculosis.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Dec 2013

Nagai Yuhki, Iwade Yoshito, Hayakawa Eri, Nakano Manabu, Sakai Takashi, Mitarai Satoshi, Katayama Masahiko, Nosaka Tetsuya, Yamaguchi Tetsuo

Abstract excerpt

We developed and evaluated a high resolution melting (HRM) curve assay by using real-time PCR for the detection of the most frequent mutations of Mycobacterium tuberculosis, which are responsible for the resistance of four anti-TB drugs: rifampicin, isoniazid, ethambutol, and streptomycin. The HRM assay was successfully used for the detection of dominant mutations: A516V, H526A, H526T, S531L, L533P, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23793795
DOI: 10.1007/s10156-013-0636-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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