Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes.

doi:10.1038/srep17127

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Article

Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes.

Scientific reports - 26 Nov 2015

Petrosyan Armen, Cheng Pi-Wan, Clemens Dahn L, Casey Carol A

Abstract excerpt

The hepatic asialoglycoprotein receptor (ASGP-R) is posttranslationally modified in the Golgi en route to the plasma membrane, where it mediates clearance of desialylated serum glycoproteins. It is known that content of plasma membrane-associated ASGP-R is decreased after ethanol exposure, although the mechanisms remain elusive. Previously, we found that formation of compact Golgi requires dimerization of the...

Topics

Alcohol Dehydrogenase
Animals
Asialoglycoprotein Receptor
COP-Coated Vesicles
Down-Regulation
Endoplasmic Reticulum
Ethanol
Gene Silencing
Golgi Apparatus
Golgi Matrix Proteins
Hep G2 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatocytes

Humans

Liver

Membrane Proteins

Metabolome

Mice

Models, Biological

Source

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Identifiers

PMID: 26607390
DOI: 10.1038/srep17127
PMCID: PMC4660820

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PDIA3

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