Article
Dynamics of Golgi matrix proteins after the blockage of ER to Golgi transport.
Journal of biochemistry - 1 Feb 2004
Yoshimura Shin-ichiro, Yamamoto Akitsugu, Misumi Yoshio, Sohda Miwa, Barr Francis A, Fujii Gourou, Shakoori Abbas, Ohno Hiroshi, Mihara Katsuyoshi, Nakamura Nobuhiro
Abstract excerpt
When the ER to Golgi transport is blocked by a GTP-restricted mutant of Sar1p (H79G) in NRK-52E cells, most Golgi resident proteins are transported back into the ER. In contrast, the cis-Golgi matrix proteins GM130 and GRASP65 are retained in punctate cytoplasmic structures, namely Golgi remnants. Significant amounts of the medial-Golgi matrix proteins golgin-45, GRASP55 and giantin are retained in the Golgi...
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