Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone mineralization-dependent craniosynostosis and craniofacial shape abnormalities in the mouse model of infantile hypophosphatasia.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2016

Durussel John, Liu Jin, Campbell Cassandra, Nam Hwa K, Hatch Nan E

Abstract excerpt

BACKGROUND: Inactivating mutations in tissue-nonspecific alkaline phosphatase (TNAP) cause hypophosphatasia (HPP), which is commonly characterized by decreased bone mineralization. Infants and mice with HPP can also develop craniosynostosis and craniofacial shape abnormalities, although the mechanism by which TNAP deficiency causes these craniofacial defects is not yet known. Manifestations of HPP are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkaline Phosphatase
Share to Craniofacial Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Craniosynostoses

Share to Disease Models, Animal

Share to Hypophosphatasia

Share to Mice, Knockout

Share to Phenotype

Source

Identifiers

PMID: 26605996
DOI: 10.1002/dvdy.24370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone mineralization-dependent craniosynostosis and craniofacial shape abnormalities in the mouse model of infantile hypophosphatasia.PMID 26605996Read ↗

Conditional <i>Alpl</i> Ablation Phenocopies Dental Defects of HypophosphatasiaSemantic proximity Read ↗

Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations.Semantic proximity Read ↗

Cranial Neural Crest Specific Deletion of TNAP Causes Abnormal Chondrocyte Maturation and Deficient Cranial Base GrowthSemantic proximity Read ↗

Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2 <sup>C342Y/+</sup> mouse models of Crouzon syndromeSemantic proximity Read ↗

TNAP and PHOSPHO1 function synergistically to afford critical control over the mineralisation of the postnatal murine skeletonSemantic proximity Read ↗

Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl-/- Mice.Semantic proximity Read ↗

GNAS locus: bone related diseases and mouse modelsSemantic proximity Read ↗

Skeletal dysplasias caused by a disruption of skeletal patterning and endochondral ossificationSemantic proximity Read ↗

Dentoalveolar Defects of Hypophosphatasia are Recapitulated in a Sheep Knock-In Model.Semantic proximity Read ↗

Tooth root dentin mineralization defects in a mouse model of hypophosphatasia.Semantic proximity Read ↗

Dental and craniofacial defects in the Crtap-/- mouse model of osteogenesis imperfecta type VII.Semantic proximity Read ↗

Diseases of the tooth: the genetic and molecular basis of inherited anomalies affecting the dentitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.