Article
Dentoalveolar Defects of Hypophosphatasia are Recapitulated in a Sheep Knock-In Model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2022
Mohamed Fatma F, Chavez Michael B, Huggins Shannon, Bertels Joshua, Falck Alyssa, Suva Larry J, Foster Brian L, Gaddy Dana
Abstract excerpt
Hypophosphatasia (HPP) is the inherited error-of-metabolism caused by mutations in ALPL, reducing the function of tissue-nonspecific alkaline phosphatase (TNAP/TNALP/TNSALP). HPP is characterized by defective skeletal and dental mineralization and is categorized into several clinical subtypes based on age of onset and severity of manifestations, though premature tooth loss from acellular cementum defects is...
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