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Article

GNAS locus: bone related diseases and mouse models

18 Oct 2023

Abstract excerpt

GNASis a complex locus characterized by multiple transcripts and an imprinting effect. It orchestrates a variety of physiological processes via numerous signaling pathways. Human diseases associated with the GNAS gene encompass fibrous dysplasia (FD), Albright’s Hereditary Osteodystrophy (AHO), parathyroid hormone(PTH) resistance, and Progressive Osseous Heteroplasia (POH), among others. To facilitate the study...

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PMID: 37920253
DOI: 10.3389/fendo.2023.1255864

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