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Article

Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl-/- Mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2021

Kinoshita Yuka, Mohamed Fatma F, Amadeu de Oliveira Flavia, Narisawa Sonoko, Miyake Koichi, Foster Brian L, Millán José Luis

Abstract excerpt

Hypophosphatasia (HPP) is caused by loss-of-function mutations in the ALPL gene that encodes tissue-nonspecific alkaline phosphatase (TNAP), whose deficiency results in the accumulation of extracellular inorganic pyrophosphate (PPi ), a potent mineralization inhibitor. Skeletal and dental hypomineralization characterizes HPP, with disease severity varying from life-threatening perinatal or infantile forms to...

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Identifiers

PMID: 34076297
DOI: 10.1002/jbmr.4382
PMCID: PMC8446309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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