Article

Cranial Neural Crest Specific Deletion of TNAP Causes Abnormal Chondrocyte Maturation and Deficient Cranial Base Growth

2023-08-30

Abstract excerpt

Bone growth plate abnormalities and skull shape defects are seen in hypophosphatasia, a heritable disorder in humans that occurs due to deficiency of Tissue Nonspecific Alkaline Phosphatase (TNAP, Alpl) enzyme activity. Abnormal development of the cranial base growth plates (synchondroses) and abnormal skull shapes have also been demonstrated in global TNAP-/- mice. To distinguish local vs. systemic effects of TNA...

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Literature Corpus work: c0bc68f6-69f9-590c-ac00-e1a5445dbb92
DOI: 10.20944/preprints202308.1993.v1

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