Article
Dental and craniofacial defects in the Crtap-/- mouse model of osteogenesis imperfecta type VII.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2020
Xu He, Lenhart Sydney A, Chu Emily Y, Chavez Michael B, Wimer Helen F, Dimori Milena, Somerman Martha J, Morello Roy, Foster Brian L, Hatch Nan E
Abstract excerpt
BACKGROUND: Inactivating mutations in the gene for cartilage-associated protein (CRTAP) cause osteogenesis imperfecta type VII in humans, with a phenotype that can include craniofacial defects. Dental and craniofacial manifestations have not been a focus of case reports to date. We analyzed the craniofacial and dental phenotype of Crtap-/- mice by skull measurements, micro-computed tomography (micro-CT),...
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