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Quisinostat treatment improves histone acetylation and developmental competence of porcine somatic cell nuclear transfer embryos

22 Feb 2017

Abstract excerpt

Abnormal epigenetic modifications are considered a main contributing factor to low cloning efficiency. In the present study, we explored the effects of quisinostat, a novel histone deacetylase inhibitor, on blastocyst formation rate in porcine somatic-cell nuclear transfer (SCNT) embryos, on acetylation of histone H3 lysine 9 (AcH3K9), and on expression of POU5F1 protein and apoptosis-related genes BAX and BCL2....

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PMID: 28224725
DOI: 10.1002/mrd.22787

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