Article
Glioblastomas with IDH1/2 mutations have a short clinical history and have a favorable clinical outcome.
Japanese journal of clinical oncology - 1 Jan 2016
Ohno Makoto, Narita Yoshitaka, Miyakita Yasuji, Matsushita Yuko, Arita Hideyuki, Yonezawa Motoki, Yoshida Akihiko, Fukushima Shintaro, Takami Hirokazu, Ichimura Koichi, Shibui Soichiro
Abstract excerpt
OBJECTIVE: Glioblastomas with isocitrate dehydrogenase 1/2 mutations comprise a biologically distinct subgroup of glioblastomas. We studied isocitrate dehydrogenase 1/2 mutant glioblastomas at the clinical, molecular and radiological levels to define their clinical features, including the prognostic value of isocitrate dehydrogenase 1/2 mutations compared with isocitrate dehydrogenase 1/2 wild-type glioblastomas....
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