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Article

Long-term survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2013

Hartmann Christian, Hentschel Bettina, Simon Matthias, Westphal Manfred, Schackert Gabriele, Tonn Jörg C, Loeffler Markus, Reifenberger Guido, Pietsch Torsten, von Deimling Andreas, Weller Michael

Abstract excerpt

PURPOSE: The determinants of long-term survival in glioblastoma have remained largely obscure. Isocitrate dehydrogenase (IDH) 1 or 2 mutations are common in World Health Organization (WHO) grades II and III gliomas, but rare in primary glioblastomas, and associated with longer survival. EXPERIMENTAL DESIGN: We compared clinical and molecular characteristics of 69 patients with centrally confirmed glioblastoma and...

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Combined Modality Therapy
DNA Modification Methylases
DNA Repair Enzymes
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

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Identifiers

PMID: 23918605
DOI: 10.1158/1078-0432.CCR-13-0017

Genes

IDH1
MGMT
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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