Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular pathogenesis of IDH mutations in gliomas.

Brain tumor pathology - 1 Jul 2012

Ichimura Koichi

Abstract excerpt

The isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) genes are mutated in 50-80% of astrocytomas, oligodendrogliomas or oligoastrocytomas of grades II and III, and secondary glioblastomas; they are, however, seldom mutated in primary glioblastomas and never in other types of glioma. Gliomas with IDH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to IDH1 gene
Share to IDH2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TET2 gene

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Mutation

Source

Identifiers

PMID: 22399191
DOI: 10.1007/s10014-012-0090-4

Genes

IDH1
IDH2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22399191-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular pathogenesis of IDH mutations in gliomas.PMID 22399191Read ↗

IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma.Semantic proximity Read ↗

IDH1 and IDH2 mutations in gliomas.Semantic proximity Read ↗

Isocitrate dehydrogenase 1 and 2 mutations in gliomas.Semantic proximity Read ↗

Bridging Cancer Biology with the Clinic: Comprehending and Exploiting IDH Gene Mutations in Gliomas.Semantic proximity Read ↗

Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics DevelopmentSemantic proximity Read ↗

Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors.Semantic proximity Read ↗

Isocitrate dehydrogenase mutations in gliomas.Semantic proximity Read ↗

Isocitrate dehydrogenase mutations: a challenge to traditional views on the genesis and malignant progression of gliomas.Semantic proximity Read ↗

Role of isocitrate dehydrogenase in glioma.Semantic proximity Read ↗

IDH1/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis.Semantic proximity Read ↗

Metabolism of glioma and IDH1/IDH2 mutations.Semantic proximity Read ↗

IDH mutations associated impact on related cancer epidemiology and subsequent effect toward HIF-1α.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.