Article
Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism.
Physiological genomics - 1 Feb 2016
Lemos José R, Alves Cleber R, de Souza Sílvia B C, Marsiglia Julia D C, Silva Michelle S M, Pereira Alexandre C, Teixeira Antônio L, Vieira Erica L M, Krieger José E, Negrão Carlos E, Alves Guilherme B, de Oliveira Edilamar M, Bolani Wladimir, Dias Rodrigo G, Trombetta Ivani C
Abstract excerpt
Besides neuronal plasticity, the neurotrophin brain-derived neurotrophic factor (BDNF) is also important in vascular function. The BDNF has been associated with angiogenesis through its specific receptor tropomyosin-related kinase B (TrkB). Additionally, Val66Met polymorphism decreases activity-induced BDNF. Since BDNF and TrkB are expressed in vascular endothelial cells and aerobic exercise training can increase...
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