Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community.

doi:10.1161/JAHA.114.001544

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Article

Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community.

Journal of the American Heart Association - 11 Mar 2015

Kaess Bernhard M, Preis Sarah R, Lieb Wolfgang, Beiser Alexa S, Yang Qiong, Chen Tai C, Hengstenberg Christian, Erdmann Jeanette, Schunkert Heribert, Seshadri Sudha, Vasan Ramachandran S, Assimes Themistocles L, Deloukas Panos, Holm Hilma, Kathiresan Sekar, König Inke R, McPherson Ruth, Reilly Muredach P, Roberts Robert, Samani Nilesh J, Stewart Alexandre F R

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a pleiotropic peptide involved in maintaining endothelial integrity. It is unknown if circulating BDNF levels are associated with risk of cardiovascular disease (CVD). METHODS AND RESULTS: We prospectively investigated the association of circulating BDNF levels with cardiovascular events and mortality in 3687 participants (mean age 65 years, 2068 women) from...

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PMID: 25762803
DOI: 10.1161/JAHA.114.001544
PMCID: PMC4392437

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BDNF
CAD

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