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Article

Composition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response During Telbivudine Therapy.

Scientific reports - 24 Nov 2015

Zhou Bin, Dong Hui, He Yungang, Sun Jian, Jin Weirong, Xie Qing, Fan Rong, Wang Minxian, Li Ran, Chen Yangyi, Xie Shaoqing, Shen Yan, Huang Xin, Wang Shengyue, Lu Fengming, Jia Jidong, Zhuang Hui, Locarnini Stephen, Zhao Guo-Ping, Jin Li, Hou Jinlin

Abstract excerpt

Reverse transcriptase (RT) mutations contribute to hepatitis B virus resistance during antiviral therapy with nucleos(t)ide analogs. However, the composition of the RT quasispecies and their interactions during antiviral treatment have not yet been thoroughly defined. In this report, 10 patients from each of 3 different virological response groups, i.e., complete virological response, partial virological response...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26599443
DOI: 10.1038/srep17123
PMCID: PMC4657086

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