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Article

Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment.

The Journal of general virology - 1 Nov 2015

Yin Feifei, Wu Zeguang, Fang Wei, Wu Chunchen, Rayner Simon, Han Meifang, Deng Fei, Du Ruikun, Liu Jinliang, Wang Manli, Wang Hualin, Ning Qin, Hu Zhihong

Abstract excerpt

Ultra-deep pyrosequencing (UDPS) was used to analyse the dynamics of quasispecies and resistant mutations during telbivudine (LDT) treatment of hepatitis B patients. Twenty-six HBeAg-positive chronic hepatitis B patients were treated with LDT for a period of 104 weeks and were characterized as 16 responders, six partial responders and four viral breakthrough patients based on hepatitis B virus (HBV) DNA levels....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26382925
DOI: 10.1099/jgv.0.000285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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