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Article

Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.

Emerging microbes & infections - 1 Dec 2020

Fu Ya, Wu Songhang, Hu Yuhai, Chen Tianbin, Zeng Yongbin, Liu Can, Ou Qishui

Abstract excerpt

Background and Aims: The drug resistance of hepatitis B virus (HBV) originates from mutations within HBV reverse transcriptase (RT) region during the prolonged antiviral therapy. So far, the characteristics of how these mutations distribute and evolve in the process of therapy have not been clarified yet. Thus we aimed to investigate these characteristics and discuss their contributing factors. Methods: HBV RT...

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Identifiers

PMID: 33124952
DOI: 10.1080/22221751.2020.1835446
PMCID: PMC7605321

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