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Article

Study of the Association of Single Nucleotide Polymorphisms in Candidate Genes With Sevoflurane.

Journal of clinical pharmacology - 1 Jan 2023

Zhao Shuai, Huang Shiqian, Zhong Qi, Han Linlin, Wang Yafeng, Xu Feng, Ma Lulin, Ding Yuanyuan, Xia Leiming, Chen Xiangdong

Abstract excerpt

The susceptibility of different individuals to anesthetics varies widely, and sevoflurane is no exception. We hypothesized that polymorphisms in genes involved in pharmacokinetics and pharmacodynamics may explain this variation. A total of 151 individuals undergoing otorhinolaryngology surgery were included. The influence of genetic polymorphisms on sevoflurane sensitivity were investigated through SNaPshot...

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PMID: 35943164
DOI: 10.1002/jcph.2138

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