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Article

Antibiotic combination therapy can select for broad-spectrum multidrug resistance in Pseudomonas aeruginosa.

International journal of antimicrobial agents - 1 Jan 2016

Vestergaard Martin, Paulander Wilhelm, Marvig Rasmus L, Clasen Julie, Jochumsen Nicholas, Molin Søren, Jelsbak Lars, Ingmer Hanne, Folkesson Anders

Abstract excerpt

Combination therapy with several antibiotics is one strategy that has been applied in order to limit the spread of antimicrobial resistance. We compared the de novo evolution of resistance during combination therapy with the β-lactam ceftazidime and the fluoroquinolone ciprofloxacin with the resistance evolved after single-drug exposure. Combination therapy selected for mutants that displayed broad-spectrum...

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Identifiers

PMID: 26597931
DOI: 10.1016/j.ijantimicag.2015.09.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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