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Article

279(Val→Phe) Polymorphism of lipoprotein-associated phospholipase A(2) resulted in changes of folding kinetics and recognition to substrate.

Computational biology and chemistry - 1 Dec 2015

Masbuchin Ainun Nizar, Rohman Mohammad Saifur, Putri Jayarani Fatimah, Cahyaningtyas Miryanti, Widodo

Abstract excerpt

INTRODUCTION: PLA2G7 encodes Lp-PLA2 having role in the formation of atherosclerotic plaques by catalyzing its substrate, phosphatydilcholine (PC), to be pro-inflammatory substances. The increased risk for coronary artery disease (CAD) in Asian population has been related with this enzyme. 279(Val→Phe) variant was reported to have a protective role against CAD due to, in part, secretion defect or loss of...

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Identifiers

PMID: 26595893
DOI: 10.1016/j.compbiolchem.2015.10.001

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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