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Article

Structural analyses of apolipoprotein A-IV polymorphisms Q360H and T347S elucidate the inhibitory effect against thrombosis.

The Journal of biological chemistry - 1 Apr 2025

Shoara Aron A, Slavkovic Sladjana, Neves Miguel A D, Bhoria Preeti, Prifti Viktor, Chen Pingguo, Donaldson Logan W, Beckett Andrew N, Johnson Philip E, Ni Heyu

Abstract excerpt

Apolipoprotein A-IV (apoA-IV) is an abundant lipid-binding protein in blood plasma. We previously reported that apoA-IV, as an endogenous inhibitor, competitively binds platelet αIIbβ3 integrin from its N-terminal residues, reducing the potential risk of thrombosis. This study aims to investigate how the apoA-IVQ360H and apoA-IVT347S mutations affect the structure and function of apoA-IV. These mutations are...

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Identifiers

PMID: 40074081
DOI: 10.1016/j.jbc.2025.108392
PMCID: PMC12017984

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