Article

Structural analyses of apolipoprotein A-IV polymorphisms Q360H and T347S elucidate the inhibitory effect against thrombosis

2024-10-21

Abstract excerpt

Apolipoprotein A-IV (apoA-IV) is an abundant lipid-binding protein in blood plasma. We previously reported that apoA-IV, as an endogenous inhibitor, competitively binds platelet αIIbβ3 integrin from its N-terminal residues, reducing the potential risk of thrombosis. This study aims to investigate how the apoA-IV Q360H and apoA-IV T347S mutations affect the structure and function of apoA-IV. These mutations are l...

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Literature Corpus work: 98771efd-a8a1-5bb4-93f0-8f8be5e1c1b4
DOI: 10.1101/2024.10.21.619523

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