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Article

In Silico Insights into Protein-protein Interaction Disruptive Mutations in the PCSK9-LDLR complex.

International journal of molecular sciences - 25 Feb 2020

Martin William R, Lightstone Felice C, Cheng Feixiong

Abstract excerpt

Gain-of-function mutations in PCSK9 (proprotein convertase subtilisin/kexin type 9) lead to reduced uptake of LDL (low density lipoprotein) cholesterol and, therefore, increased plasma LDL levels. However, the mechanism by which these mutants reduce LDL reuptake is not fully understood. Here, we have used molecular dynamics simulations, MM/PBSA (Molecular Mechanics/Poisson-Boltzmann Surface Area) binding affinity...

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Identifiers

PMID: 32106405
DOI: 10.3390/ijms21051550
PMCID: PMC7084799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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