Article

Structural Dynamics of LDL Receptor Interactions with E498A and R499G Variants of PCSK9

2024-07-26

Abstract excerpt

The low-density lipoprotein receptor (LDLR) plays an integral role in cellular cholesterol uptake and lipid metabolism by primarily regulating hepatic clearance of plasma low-density lipoprotein cholesterol (LDL-C). Physiologically, proprotein convertase subtilisin/kexin type-9 (PCSK9) attenuates LDLR function by binding to the LDLR extracellular domain, leading to its lysosomal degradation and thereby preventing...

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Literature Corpus work: 8c86657b-ced6-568b-b73e-21c46c04aaa2
DOI: 10.1101/2024.07.25.605225

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