Characterization of the I4399M variant of apolipoprotein(a): implications for altered prothrombotic properties of lipoprotein(a).

doi:10.1111/jth.13759

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Article

Characterization of the I4399M variant of apolipoprotein(a): implications for altered prothrombotic properties of lipoprotein(a).

Journal of thrombosis and haemostasis : JTH - 1 Sept 2017

Scipione C A, McAiney J T, Simard D J, Bazzi Z A, Gemin M, Romagnuolo R, Macrae F L, Ariëns R A, Hegele R A, Auld J, Gauld J W, Boffa M B, Koschinsky M L

Abstract excerpt

Essentials Elevated lipoproteinp(a) is an independent and causal risk factor for atherothrombotic diseases. rs3798220 (Ile/Met substitution in apo(a) protease-like domain) is associated with disease risk. Recombinant I4399M apo(a) altered clot structure to accelerate coagulation/delay fibrinolysis. Evidence was found for increased solvent exposure and oxidation of Met residue. SUMMARY: Background Lipoprotein(a)...

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PMID: 28632940
DOI: 10.1111/jth.13759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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