Article
A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.
Cell research - 1 Jan 2023
Cheng Rongjie, Li Fanying, Zhang Maolei, Xia Xin, Wu Jianzhuang, Gao Xinya, Zhou Huangkai, Zhang Zhi, Huang Nunu, Yang Xuesong, Zhang Yaliang, Shen Shunli, Kang Tiebang, Liu Zexian, Xiao Feizhe, Yao Hongwei, Xu Jianbo, Yan Chao, Zhang Nu
Abstract excerpt
Mutations of the RAS oncogene are found in around 30% of all human cancers yet direct targeting of RAS is still considered clinically impractical except for the KRASG12C mutant. Here we report that RAS-ON (RASON), a novel protein encoded by the long intergenic non-protein coding RNA 00673 (LINC00673), is a positive regulator of oncogenic RAS signaling. RASON is aberrantly overexpressed in pancreatic ductal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.