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Article

Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil.

Molecular oncology - 1 Aug 2026

Sain Radhika, Le Page Yann, Percevault Frédéric, Becker Emmanuelle, Negroni Luc, Fernandez Almudena, Cantero Marta, Muñoz-Santos Diego, Montoliu Lluís, Garnier Cyrille, Primig Michael

Abstract excerpt

The 3'-5' exoribonuclease EXOSC10 degrades aberrant mRNAs and noncoding RNAs in cooperation with the nuclear RNA exosome. EXOSC10's localization and stability are regulated by sumoylation and proteasomal degradation in response to stress, and the protein is essential for cell growth and proliferation, fertility, hematopoiesis, and brain development. EXOSC10 is a cancer biomarker; its activity is inhibited by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42138069
DOI: 10.1002/1878-0261.70239
PMCID: PMC13398982

Genes

EXOSC10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil.PMID 42138069Read ↗

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