Article
Diverse in vivo effects of soluble and membrane-bound M-CSF on tumor-associated macrophages in lymphoma xenograft model.
Oncotarget - 12 Jan 2016
Liao Jinfeng, Feng Wenli, Wang Rong, Ma Shihui, Wang Lina, Yang Xiao, Yang Feifei, Lin Yongmin, Ren Qian, Zheng Guoguang
Abstract excerpt
Macrophage colony-stimulating factor (M-CSF) is an important cytokine for monocyte/macrophage lineage. Secretory M-CSF (sM-CSF) and membrane-bound M-CSF (mM-CSF) are two major alternative splicing isoforms. The functional diversity of these isoforms in the activation of tumor-associated macrophages (TAMs), especially in lymphoma microenvironment, has not been documented. Here, we studied the effects of M-CSF...
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