Article
Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process.
Translational psychiatry - 11 Jul 2022
Delli Colli Claudia, Borgi Marta, Poggini Silvia, Chiarotti Flavia, Cirulli Francesca, Penninx Brenda W J H, Benedetti Francesco, Vai Benedetta, Branchi Igor
Abstract excerpt
The serotonin-transporter-linked promoter region (5-HTTLPR) has been widely investigated as contributing to depression vulnerability. Nevertheless, empirical research provides wide contrasting findings regarding its involvement in the etiopathogenesis of the disorder. Our hypothesis was that such discrepancy can be explained considering time as moderating factor. We explored this hypothesis, exploiting a meta...
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